NOW® Melatonin has a minimum purity of 99%.
Melatonin is a hormone found naturally in the body but is made synthetically in a laboratory for supplemental purposes. Melatonin is typically used for the inability to fall asleep (insomnia); delayed sleep phase syndrome (DSPS); insomnia associated with attention deficit-hyperactivity disorder (ADHD); insomnia due to certain high blood pressure medications called beta-blockers; and sleep problems in children with developmental disorders including autism and cerebral palsy.
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that is primarily produced by the pineal gland, located behind the third ventricle in the brain. In the synthesis of melatonin, tryptophan is hydroxylated to 5-hydroxytryptophan, which in turn is decarboxylated to 5-hydroxytryptamine (serotonin). Serotonin is converted to the melatonin precursor and metabolite Nacetylserotonin by the enzyme N-acetyl transferase. N-acetylserotonin is methylated via the enzyme hydroxyindole-o-methyltransferase to produce melatonin. Approximately 90 percent of melatonin is cleared in a single passage through the liver. A small proportion of unmetabolized melatonin is also excreted in the urine.
Serving Size: 1 Capsule
Servings Per Container: 180
Melatonin 3 mg
Other Ingredients: Rice Flour and Gelatin (capsule).
Suggested Use: As a dietary supplement, take one capsule near bedtime with water. Capsule may be opened and the contents divided over several evenings if desired.
Caution: If you are under medical supervision seek the advice of your physician or health care professional prior to use. Individuals with auto-immune conditions, depressive disorders, those taking sedatives or corticosteroid drugs, or pregnant or lactating women should consult their physician prior to use. This product may cause drowsiness. Do not operate a vehicle or heavy machinery following consumption of melatonin. Keep out of reach of children.